头颈部放射性口腔黏膜炎患者营养状况与生活质量相关性研究

Correlation between nutritional status and quality of life in patients with head and neck radioactive oral mucositis

目的 探讨头颈部肿瘤放射性口腔黏膜炎的患者营养状况与生活质量的相关性.方法 采用一般资料问卷、癌症患者生活质量量表(QLQ-C30)、患者主管整体评定量表(PG-SGA)、美国国家癌症研究所常见毒性反应标准(NCI-CTCAE)量表对80例头颈部放射性口腔黏膜炎患者进行调查.结果 80例符合入选标准的患者,其中男51例,女29例.年龄19 ~80(58.21±11.84)岁.PG-SGA评价结果:A级患者为12例,B级患者为35例,C级患者为33例.躯体功能、角色功能、认知功能、社会功能、总体健康状况及疲倦、疼痛、便秘、腹泻等症状与营养状况存在明显相关性(P<0.05),情绪功能、恶心呕吐、气促、失眠、食欲丧失、经济困难与营养状况无明显相关性(P>0.05).结论 头颈部放射性口腔黏膜炎患者存在着不同程度的营养不良,其营养状况与生活质量呈正相关关系(P<0.01).因此,改善头颈部放射性口腔黏膜炎患者的营养状况可大幅度提高患者的生活质量,改善临床治疗结局,为今后制定护理干预措施提供参考依据.

Objective To investigate the correlation between nutritional status and quality of life in patients with head and neck tumors with radiation-induced oral mucositis.Method A total of 80 patients with head and neck radioactivity were investigated using the General Information Questionnaire,the Quality of Life Scale for Cancer Patients(QLQ-C30),the Patient Supervisory Overall Rating Scale(PG-SGA),and the National Cancer Institute Common Toxicity Response Standard(NCI-CTCAE)Patients with oral mucositis were investigated.Result In total of 80 patients met the selection criteria,including 51 males and 29 females.The age ranged from 19 to 80 years,with an average age of(58.21±11.84)years.PG-SGA evaluation results:There were 12 cases of Grade A patients,35 cases of Grade B patients,and 33 cases of Grade C patients.Physical function,role function,cognitive function,social function,general health and fatigue,pain,constipation,diarrhea and other symptoms were significantly correlated with nutritional status(P<0.05),emotional function,nausea There was no significant correlation between vomiting,shortness of breath,insomnia,loss of appetite,economic difficulties and nutritional status(P>0.05).Conclusions Patients with head and neck radiation oral mucositis had malnutrition to varying degrees,and their nutritional status was positively correlated with quality of life(P<0.01).Therefore,improving the nutritional status of patients with head and neck radiation oral mucositis can greatly improve the quality of life of patients,improve clinical treatment outcomes,and provide reference basis for future nursing interventions.