多参数磁共振成像在前列腺癌诊疗方面的研究进展

Progress in multi-modal magnetic resonance imaging in the diagnosis and treatment of prostate cancer

前列腺癌是我国男性比较常见的泌尿系统恶性肿瘤,随着我国人口的老龄化以及人们生活方式的改变,其发病率和死亡率逐渐增高,已严重威胁人们的健康,其发病率在2030年有望增加1倍.多参数磁共振成像(Mp-MRI)是一种将解剖学磁共振成像(MRI)与一个或多个功能性MR成像序列相结合的全新的成像模态.Mp-MRI的传统作用仅限于前列腺癌的分期,但随着物理学以及医学的不断发展,多样的成像序列也被不断开发并应用于临床.目前Mp-MRI序列包括常规T1、T2加权成像和功能MRI,如动态对比增强磁共振成像(DCE-MRI)、弥散加权成像(DWI)、磁共振波谱(MRS)和磁共振光谱成像(MRSI)等,其作用已扩展到临床诊疗的各个阶段,包括前列腺癌的检测、定位、侵袭性评估以及肿瘤分期、治疗疗效的评价,提供了评估肿瘤生物学行为的非侵入性解决方案.本文就Mp-MRI在前列腺癌临床诊疗中的应用以及其优势与不足进行综述,展望Mp-MRI在前列腺疾病诊疗中的新定位.

Prostate cancer is a common malignant tumor in men.With the aging of the population and the changes of people\s lifestyle,its incidence rate and mortality rate have been increasing.It has seriously threatened people\s health,its incidence rate is expected to double in 2030.Multiparameter magnetic resonance imaging(Mp-MRI)is a new imaging modality that combines anatomical MR imaging(MRI)with one or more functional MR imaging sequences.The traditional role of Mp-MRI is limited to PCa staging,but with the continuous development of physics and medicine,a variety of imaging sequences have been developed and applied in clinical.At present,Mp-MRI sequence includes conventional T1,T2 weighted imaging and functional MRI,such as dynamic contrast-enhanced MRI(DCE-MRI),diffusion-weighted imaging(DWI),magnetic resonance spectroscopy(MRS)and magnetic resonance spectroscopy(MRSI),etc.Its role has been extended to all stages of clinical diagnosis and treatment,including detection,localization,invasive evaluation,tumor stage,the evaluation of therapeutic effect,provides a non-invasive solution to evaluate the biological behavior of tumor.This paper reviews the application of Mp-MRI in the clinical diagnosis and treatment of prostate cancer,its advantages and disadvantages,and looks forward to the new location of multiparameter Mp-MRI in the diagnosis and treatment of prostate diseases.