小儿炎症性肠炎与细胞外基质重构相关性分析

Correlation Analysis Between Infantile Inflammatory Enteritis and Extracellular Matrix Remodeling

目的通过在对患有炎症性肠炎的幼儿的临床治疗中,探讨分析幼儿患炎症性肠炎与细胞外基质重构之间的相关性。方法选取80例患有炎症性肠炎的患儿作为观察组,其中男性幼儿患者为44例;女性幼儿患者为36例;本组患儿的疾病类型包括溃疡性结肠炎35例以及克罗恩病患儿45例,同时选取同时期在我院接受体检的健康儿童40名,将其设定为对照组。比较三组的炎症因子水平。结果炎症性肠炎患儿血清炎症水平高于对照组,差异具有统计学意义(P<0.05)。结论小儿炎症肠炎发病时细胞外基质降解和重构发挥着重要作用。

Objective To explore the relationship between inflammatory enteritis and extracellular matrix remodeling in children. Methods 80 children with inflammatory enteritis were selected as the observation group, of which 44 were male children, 36 were female children, 35 were ulcerative colitis and 45 were Crohn’s disease. 40 healthy children who received physical examination in our hospital at the same time were selected as the control group. The levels of inflammatory factors in the three groups were compared. Results the level of serum inflammation in children with inflammatory enteritis was significantly higher than that in the control group(P < 0.05). Conclusion Extracellular matrix degradation and remodeling play an important role in the pathogenesis of inflammatory enteritis in children.