桥本氏甲状腺炎患者年龄、性别分布及自身免疫抗体水平分析

Analysis of the Age,Sex Distribution and Autoimmune Antibody level of The Prevalent with Hashimoto's Thyroiditis

目的:分析桥本氏甲状腺炎(HT)在不同年龄男女性患者分布差异及相关抗体水平变化特点。方法:2014-01-01—2018-12-31五年间本院收治的HT患者共2705例,先按年龄分为儿童组(n=32)、青春期组(n=135)和成人组(n=2538),再将成人组中女性分为≤50岁组(n=1645)及>50岁组(n=519)两组,比较不同年龄组HT男女性占比差异,分析不同年龄组以及50岁前后女性甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TgAb)的水平变化。结果:在三年龄组中,HT总病例数以成人组最多,儿童组较少。各年龄组间男性、女性HT占比差异有统计学意义(P<0.01);各年龄组内女性占比均显著高于男性,尤以成人组女性占比最高(P<0.01)。三年龄组间TPOAb、TgAb水平有显著统计学意义(均P<0.01)。青春期组及成人组TPOAb水平均低于儿童组(P<0.01),成人组与青春期组TPOAb水平差异无统计学意义(P>0.05);青春期组TgAb水平低于儿童组(P<0.01),儿童组与成人组间、青春期组与成人组间TgAb水平的差异均无统计学意义(P>0.05)。≤50岁与>50岁女性的TPOAb和TgAb水平比较均无统计学差异(P>0.05)。结论:成年人(>18岁)HT明显多于非成年人,且女性占比显著高于男性。TPOAb下降可能是成人HT的内分泌影响因素之一。

Objective:To analyze the distribution of Hashimoto's thyroiditis(HT)in different ages of male and female patients and the characteristics of the change of antibody level.Method:From January 1,2014 to December 31,2018,2705 HT patients were admitted to our hospital.According to the age,they were divided into children group(n=32),adolescence group(n=135)and adult group(n=2538).Then,women in the adult group were divided into two groups:the group≤50 years old(n=1645)and the group>50 years old(n=519).The sex ratio difference of different age groups was compared,and the thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)were analyzed.Results:Among the three age groups,the number of HT cases in adult group was the most,while that in children group was the least,and there was a significant difference in the proportion of HT between male and female(P<0.01);but the proportion of female in each age group was significantly higher than that of male,especially in the adult group(P<0.01).TPOAb and TgAb levels were significantly higher in the three age groups(P<0.01).The level of TPOAb in adolescence group and adult group was lower than that in children group(P<0.01).There was no significant difference in TPOAb between adult group and adolescence group(P>0.05).The level of TgAb in adolescence group was lower than that in children group(P<0.01).There was no significant difference in TgAb between children group and adult group,adolescence group and adult group(P>0.05).There was no significant difference in the levels of TPOAb and TgAb between women under 50 years old and women over 50 years old(P>0.05).Conclusion:HT in adults(>18 years old)is significantly higher than that in non adults,and the proportion of females is significantly higher than that of males.The decrease of TPOAb may be one of the endocrine influencing factors of adult HT.