电针治疗肝胃不和型功能性消化不良的临床疗效及对血清胃泌素、胃动素水平的影响

Clinical effect of electroacupuncture in treating functional dyspepsia of liver and stomach disharmony syndrome and its effect on GAS and MTL

目的探讨电针治疗功能性消化不良的临床疗效及对血清胃泌素、胃动素水平的影响。方法选取2017年7月至2019年2月于我院就诊的符合要求的患者100例随机分为电针组(50例)和西药组(50例),其中电针组予以针刺中脘穴、足三里穴(双侧)、太冲穴(双侧),并连接电针治疗;西药组予以莫沙必利和黛力新口服。比较两组患者治疗前后的疗效差异及血清胃泌素、胃动素水平。结果治疗后,两组患者中医症状评分在不同监测点总体呈先低后升,差异有统计学意义(F组内=19.260,P组内<0.001);从治疗后各个监测点看,西药组中医症状评分均显著高于电针组(F组间=4.266,P组间=0.013)。电针组47例中治愈10例、显效22例、有效10例、无效5例,显效率为68.09%;而西药组45例中治愈6例、显效15例、有效15例、无效9例,显效率为46.67%,电针组明显高于西药组(Z=1.994,P=0.046)。另外,治疗后两组患者的血清胃泌素水平下降,电针组下降较西药组明显;胃动素水平上升,电针组升高较西药组显著,差异均具有统计学意义(tGAS=3.723,P<0.001;tMTL=8.490,P<0.001)。结论电针治疗功能性消化不良疗效较佳,同时能够通过调节血清胃泌素和胃动素水平来增强胃动力,调节胃肠功能。

Objective To explore the clinical effect of electroacupuncture in treating functional dyspepsia of liver and stomach disharmony syndrome and its effect on gastrin and motilin.Methods 100 patients who met the requirements of our hospital from July 2017 to February 2019 were randomly divided into electroacupuncture group(EA group,50 cases)and western medicine group(WM group,50 cases).The EA group was treated with electroacupuncture at RN12,ST36(bilateral)and LR3(bilateral).The WM group was given Mosapride and Deanxit.The difference in efficacy,gastrin and motilin levels between the two groups before and after treatment were compared.Results After treatment,the TCM symptom scores of the two groups were decreased first and then increased at different monitoring points,and the difference was statistically significant(F=19.260,P<0.001).From the various monitoring points after treatment,the TCM symptom scores of the EA group were all significantly lower than the WM group(F=4.266,P=0.013).In the 47 cases of EA group,10 cases were cured,22 cases were markedly effective,10 cases were effective,5 cases were ineffective,and the markedly effective rate was 68.09%.Meanwhile in the WM group,6 cases were cured,15 cases were markedly effective,15 cases were effective,9 cases were ineffective,and the markedly effective rate was 46.67%.The efficiency of EA group was significantly higher than that of WM group(Z=1.994,P=0.046).The gastrin levels of the two groups were decreased,where the EA group decreased significantly compared with the WM group.The motilin levels of the two groups were increased,where the EA group increased significantly compared with the WM group,and the difference was statistically significant(tGAS=3.723,P<0.001;tMTL=8.490,P<0.001).Conclusion EA is effective in the treatment of functional dyspepsia,and can enhance gastric motility and regulate gastrointestinal function by regulating gastrin and motilin levels.