小胶质细胞与脓毒症脑病的研究进展

Advances in research on microglia and sepsis associated encephalopathy

脓毒症脑病(SAE)以脑功能障碍为主要特征,是脓毒症患者的常见并发症,严重影响预后和生存质量。近期研究发现,小胶质细胞作为中枢神经系统内的免疫细胞,在脓毒症条件下可发生炎性改变,促进中枢炎症反应和SAE的发展。以小胶质细胞作为靶点可能为治疗SAE提供新的思路和方向。本文简述小胶质细胞的特性及其与SAE的关系,分析小胶质细胞活化对中枢神经系统的影响,探讨调节小胶质细胞的信号通路,并对其未来临床应用进行了展望。

Sepsis associated encephalopathy(SAE),characterized by brain dysfunction,is a common complication in septic patients and seriously affects the prognosis and quality of life.Recent researches have discovered that microglia,as the immune cells in the central nervous system,can produce inflammatory transformation under septic condition and promote the development of cerebral inflammation and SAE.Targeting microglia may provide new ideas and directions for the treatment of SAE.In this paper,the characteristics of microglia were briefly described,and the relationship between microglia and SAE was expounded.The effects of microglia activation on the central nervous system were analyzed,the signaling pathway for microglia regulation was discussed,and its clinical application in the future was prospected.