STAT3信号通路在胰岛素抵抗中的研究进展

Research progress of STAT3 signaling pathway in insulin resistance

胰岛素抵抗(IR)是2型糖尿病的重要发生机制,通过影响多种信号通路传导,从而使糖代谢紊乱,信号传导与转录激活因子3(STAT3)通路是一种调控基因转录的重要通路。有证据表明,STAT3信号通路是IR的关键因子,能够调节有丝分裂原活化蛋白激酶(M APK)通路、胰岛素受体底物-1(IRS-1)磷/脂酰肌醇3激酶(P13K)蛋/白激酶B(PKB)通路等胰岛素相关通路。STAT3信号通路被上游细胞因子白细胞介素-22(IL-22)激活,参与糖代谢调节,目前是研究热点,本文就STAT3通路与IR的关系进行综述,旨在进一步阐明糖代谢紊乱机制,为糖尿病治疗提供新思路。

Insulin resistance(IR)is an important mechanism of type 2 diabetes.It affects the transmission of various signaling pathways,thereby disrupting glucose metabolism.Signaling and the transcriptional activation factor 3(STAT3)pathway are important pathways that regulate gene transcription.There is evidence that STAT3 signaling pathway is a key factor of IR,which can regulate the mitogen-activated protein kinase(MAPK)pathway,insulin receptor substrate-1(IRS-1)/phosphatidyl inositol 3 kinase(P13K)/protein kinase B(PKB)pathway and other insulin-related pathways.The STAT3 signaling pathway is activated by the upstream cytokine interleukin-22(IL-22)and is involved in the regulation of glucose metabolism.It is a current research hotspot.This article reviews the relationship between the STAT3 pathway and IR to further clarify the pathogenesis of glucose metabolism.