NLRP3炎症小体与心室重塑的研究进展

Role of NLRP3 inflammasome in ventricular remodeling

心室重塑是指心力衰竭进程中,由于适应心脏负荷的增加,多种体液因子共同参与,心肌细胞与细胞间质细胞在结构、功能、数量及遗传表形方面所出现的适应性、增生性的变化,这些变化使得心肌僵硬度变大,顺应性下降,影响心肌的舒张和收缩功能。NLRP3炎症小体是一种多蛋白复合物,参与炎症反应,并在心室重塑中也发挥着重要作用。本文针对NLRP3炎症小体与心室重塑的研究进展作一综述。

Ventricular remodeling refers to the adaptive and proliferative changes in the structure,function,quantity and genetic phenotype of cardiac myocytes and interstitial cells,in response to an increase in cardiac load and the participation of various humoral factors,during heart failure.These changes result in increased myocardial stiffness and reduced myocardial compliance,affecting the diastolic and systolic function of myocardia.NLRP3 inflammasome is a polyprotein complex,which takes part in the inflammatory response and plays an important role in ventricular remodeling.This article presents a review on the research progress of NLRP3 inflammasome and ventricular remodeling.