氨磺必利与利培酮治疗首发精神分裂症临床疗效的比较研究

Comparative study for clinical effect amisulpiride and risperidone in the treatment of first-episode schizophrenia

目的比较氨磺必利与利培酮治疗首发精神分裂症的临床疗效。方法选取北京市密云区精神卫生防治院2016年4月—2017年8月收治的首发精神分裂症患者40例,依照计算机数字表法分为参照组与试验组,各20例。参照组予以利培酮治疗,试验组予以氨磺必利治疗,两组均连续治疗2个月。比较两组阳性与阴性症状量表(PANSS)评分,临床疗效,治疗前后社会功能缺陷量表(SDSS)评分、简明精神病量表(BPRS)评分、社会功能缺陷量表(GAS)评分、治疗副反应量表(TESS)评分,并观察两组不良反应发生情况。结果试验组PANSS评分高于参照组(P<0.05)。两组临床疗效比较,差异无统计学意义(P>0.05)。治疗前两组SDSS评分、BPRS评分和GAS评分比较,差异无统计学意义(P>0.05);治疗后试验组SDSS评分、BPRS评分、TESS评分低于参照组,GAS评分高于参照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论与利培酮比较,氨磺必利治疗首发精神分裂症的临床疗效更优,其可更有效地改善患者阳性和阴性症状,提高社会功能,且安全性更高。

Objective To compare the clinical effect amisulpiride and risperidone in the treatment of first-episode schizophrenia.Methods A total of 40 cases of patients with first-episode schizophrenia were selected from April 2016 to August 2017 in Beijing Miyun District Mental Health Prevention and Control Institute,which were divided into control group and experimental group according to computer numerical table method,20 cases in each group.The control group was treated with risperidone,the experimental group was treated with amisulpiride,both groups were treated continuously for 2 months.PANSS score,clinical effect,SDSS score,BPRS score,GAS score,TESS score before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The PANSS score of the experimental group was higher than control group(P<0.05).There was no significant difference in clinical efficacy between the two groups(P>0.05).Before treatment,there was no significant differences in SDSS score,TBPRS score or GAS score between the two groups(P>0.05);after treatment,the experimental group of SDSS score,BPRS score and TESS score were lower than control group,and GAS score was higher than control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Compared with risperidone,amisulpiride is more effective in the treatment of first-episode schizophrenia,it can more effectively improve the positive and negative symptoms of patients,improve social functions,and has higher safety.