硫酸氢氯吡格雷片、阿托伐他汀钙片联合丁苯酞治疗急性进展性缺血性脑卒中效果观察

Observation on the effect of clopidogrel bisulfate tablets,atorvastatin calcium tablets and butylphthalide in the treatment of acute progressive ischemic stroke

目的观察硫酸氢氯吡格雷片(波立维)、阿托伐他汀钙片(立普妥)联合丁苯酞治疗急性进展性缺血性脑卒中(PIS)的临床效果。方法选取2018年8-12月上饶市立医院收治的PIS患者60例,采取随机数字表法分为观察组和对照组,每组30例。对照组给予波立维、立普妥治疗,观察组在对照组的基础上联合丁苯酞治疗。比较2组临床疗效、治疗前后神经功能缺损情况以及不良反应。结果观察组治疗总有效率为96.67%,高于对照组的80.00%(P<0.05);治疗后,2组神经功能缺损评分均低于治疗前,且观察组优于对照组(P均<0.01);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论波立维、立普妥联合丁苯酞治疗PIS的临床效果显著,能有效改善患者神经功能,且安全性较高,值得临床推广应用。

Objective To observe the clinical effects of clopidogrel bisulfate tablets(Plavix),atorvastatin calcium tablets(lipitor)and butylphthalide in the treatment of acute progressive ischemic stroke(PIS).Methods 60 patients with PIS who treated in the hospital from August 2018 to December 2018 were divided into observation group(30 cases)and control group(30 cases)by random number table.Control group was given plavix and lipitor,and observation group was treated with butyphthalide based on control group.The total effective rate,neurological function defect scale,adverse reactions were compared between two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 80.00%in the control group(P<0.05).After treatment,the neurological deficit scores in both groups were lower than before treatment,and the observation group was better than the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Plavix,lipitor combined with butyphthalide in treatment of PIS has significant clinical effects,it can improve nerve function and have higher safety.