环二鸟苷酸对细菌运动调控的研究进展

The Research Progress on Regulation of Bacterial Motility by Cyclic Diguanosine Monophosphate

细菌中的第二信使环二鸟苷酸(c-di-GMP)对细菌的运动性有调节作用.c-di-GMP调控鞭毛的生物合成、菌毛形成和菌毛蛋白的组成,以及其他一些与运动相关的蛋白的合成.细菌的运动性与其毒力、致病性、粘附性、趋化性、生物膜组成等密切相关.在革兰氏阴性细菌中,关于c-di-GMP的信号通路的研究较为清晰,而在革兰氏阳性细菌中,关于该信号转导通路的研究较少.此外,有关c-di-GMP的信号通路的研究主要集中在病原菌.该文主要综述了一些常见病原菌中c-di-GMP对其运动性的调控机制,为研究其他细菌c-di-GMP信号通路提供思路.

Cyclic diguanosine monophosphate(c-di-GMP)that is the second messenger in the bacteria regulates bacterial motility.c-di-GMP regulates flagellum biosynthesis,pili formation,pilin composition and synthesis of other motor-related proteins.The motility of bacteria is related to its physiological activities such as virulence,pathogenicity,adhesion,chemotaxis and biofilm composition.In Gram-negative bacteria,the signaling pathways of c-di-GMP are well documented.Nevertheless,few reports about the pathway in Gram-positive bacteria are available.Furthermore,the studies on the signaling pathway focus on pathogen.The mechanisms of bacterial motility regulated by c-di-GMP are summarized in the present paper,which provides examples for the study of c-di-GMP signaling pathway in other bacteria.