细胞外囊泡在肺部炎症性疾病中的研究进展

Progress of extracellular vesicles in the pulmonary inflammatory diseases

细胞外囊泡是一类细胞起源的,广泛存在于尿液、血液、唾液、乳汁、脑脊液和羊水等多种体液中的膜性结构。囊泡内包含核酸分子、酶类、蛋白质等生物活性物质,可通过多种途径传递其所携带的生物信息于靶细胞,参与靶细胞的多种病理生理调节过程。目前研究表明细胞外囊泡在哮喘、慢性阻塞性肺病、急性肺损伤/急性呼吸窘迫综合征等肺部炎症性疾病的发展中发挥重要作用并具有潜在的治疗价值。

Extracellular vesicles are a kind of membrane structures deriving from cells,which exist widely in urine,blood,saliva,milk,cerebrospinal fluid,amniotic fluid and other body fluid.Extracellular vesicles contain nucleic acid,enzymes,proteins and other bioactive molecules,which can convey the biological information to target cells through a variety of modes and participate in the pathophysiological processes of target cells.In recent years,it is considered that extracellular vesicles are associated with the pathogenesis of inflammatory disease of pulmonary such as asthma,chronic obstructive pulmonary disease and acute lung injury/acute respiratory distress syndrome,and have potential therapeutic value through a large body of research.