2型固有淋巴细胞在肺发育和肺损伤中的作用

Roles of type 2 innate lymphoid cells in lung development and lung injury

先天免疫作为机体防御的第一道防线,对机体防御病原体起重要作用。固有淋巴细胞(innate lymphoid cells,ILCs)是先天免疫系统中重要的效应细胞,ILC2s是ILCs的一个子集,其特点是能产生大量2型细胞因子和某些组织生长因子。ILC2s广泛存在于机体各组织,肺脏黏膜组织是ILC2s主要聚居地。ILC2s参与肺发育,也可能参与各种因素诱导的肺损伤及其组织修复。对ILC2s的进一步研究,将为我们理解肺发育和肺损伤机制提供新思路。

As the first line of defense,innate immunity plays an important role in the defense of pathogens.ILC2s,a subset of innate lymphoid cells(ILCs)which is an important effector cell in the innate immune system,can produce a large number of type 2 cytokines and some tissue growth factors.ILC2s widely exist in various tissues of the body,of which lung mucosa is the main habitat.ILC2s are involved in lung development and may also be involved in lung injury and tissue repair induced by various factors.Further study of ILC2s will provide new insights into the mechanism of lung development and lung injury.