氧化应激对肠屏障功能障碍发病的影响

Effects of oxidative stress in the pathogenesis of intestinal mucosal barrier dysfunction

机体累积过量的活性氧自由基所导致的氧化应激是多种肠道疾病发生的共同病理生理基础。肠上皮细胞间的紧密连接是维持肠屏障功能的重要结构基础之一。近年来研究表明,氧化应激能通过多种途径破坏肠上皮细胞间的紧密连接,导致肠上皮屏障功能障碍。本文对蛋白激酶C、丝裂原活化蛋白激酶、蛋白质的修饰以及缺氧诱导因子-1(HIF-1)在肠屏障功能障碍中的作用机制进行简要概述,旨在为肠屏障功能障碍的治疗和预后提供新的思路。

Oxidative stress caused by excessive accumulation of reactive oxygen free radicals is the common pathophysiological basis of many intestinal diseases. The tight junction between intestinal epithelial cells is one of the important structural bases for maintaining intestinal barrier function. Recent studies had shown that oxidative stress could destroy the tight junction between intestinal epithelial cells in a variety of ways, resulting in intestinal epithelial barrier dysfunction. In this paper, the modifications of protein kinase C, mitogen activated protein kinase and modification of proteinand and HIF-1 in intestinal barrier dysfunction were briefly reviewed. The purpose of this study is to provide a new idea for the treatment and prognosis of intestinal barrier dysfunction.