龙血通络胶囊联合长春西汀治疗血栓性脑梗死恢复期的疗效观察

Clinical observation of Longxue Tongluo Capsules combined with vinpocetine in treatment of thrombotic cerebral infarction at recovery stage

目的分析龙血通络联合长春西汀注射液治疗血栓性脑梗死恢复期的临床效果。方法选择2017年7月-2019年2月郑州大学第二附属医院收治的143例血栓性脑梗死恢复期患者,随机分成对照组(71例)和治疗组(72例)。对照组静脉滴注长春西汀注射液,30 mg加入生理盐水,1次/d。治疗组在对照组基础上口服龙血通络胶囊,2粒/次,3次/d。两组患者均治疗2周。观察两组患者临床疗效,同时比较治疗前后两组患者平均脑血流速度、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL-C)和总胆固醇(TC)水平。结果治疗后,对照组临床有效率为76.06%,显著低于治疗组的93.06%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组大脑中动脉(MCA)、大脑后动脉(PCA)、大脑前动脉(ACA)、基底动脉(BA)平均血流速度均显著增加(P<0.05),且治疗组平均血流速度明显高于对照组(P<0.05)。治疗后,两组TG、LDL和TG水平均得到明显降低(P<0.05),而HDL-C水平明显升高(P<0.05),且治疗组血脂水平均明显优于对照组(P<0.05)。结论龙血通络联合长春西汀注射液治疗脑血栓恢复期患者,可有效改善患者临床症状,促进脑部血液循环,优化神经功能和血脂水平,具有一定的临床推广应用价值。

Objective To analyze the clinical effect of Longxue Tongluo Capsules combined with Vinpocetine Injection in treatment of thrombotic cerebral infarction at recovery stage. Methods Patients(143 cases) with thrombotic cerebral infarction at recovery stage in the Second Affiliated Hospital of Zhengzhou University from July 2017 to February 2019 were randomly divided into control(71 cases) and treatment(72 cases) groups. Patients in the control group were iv administered with Vinpocetine Injection, 30 mg added into normal saline, once daily. Patients in the treatment group were po administered with Longxue Tongluo Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the average cerebral blood flow velocity, the level of TG, LDL, HDL-C, and TC in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 76.06%, which was significantly lower than 93.06% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the average cerebral blood flow velocity of MCA, PCA, ACA, and BA in two groups were significantly increased(P < 0.05), and these indexes in the treatment group were significantly higher than those in the control group(P < 0.05). After treatment, the level of TG, LDL, and TG in two groups was significantly decreased(P < 0.05), but the level of HDL-C was significantly increased(P < 0.05), and the blood lipid level in the treatment group was significantly better than that in the control group(P < 0.05). Conclusion Longxue Tongluo Capsules combined with Vinpocetine Injection in treatment of thrombotic cerebral infarction at recovery stage can effectively improve the clinical symptoms, promote cerebral blood circulation, optimize nerve function and blood lipid level, which has a certain clinical application value.