喜炎平注射液联合更昔洛韦治疗儿童流行性腮腺炎的临床研究

Clinical study on Xiyanping Injection combined with ganciclovir in treatment of mumps in children

目的探讨喜炎平注射液联合注射用更昔洛韦治疗儿童流行性腮腺炎的临床疗效。方法选取天津市宝坻区人民医院2017年3月-2019年9月收治的82例流行性腮腺炎患儿作为研究对象,按随机数字表法将所有患儿分为对照组和治疗组,每组各41例。对照组静脉滴注注射用更昔洛韦,5mg/kg,每12小时1次。治疗组在对照组治疗的基础上静脉滴注喜炎平注射液,10 mg/(kg?d)。两组患儿连续治疗7 d。观察两组患者临床疗效,同时比较治疗前后两组患儿临床症状改善情况、疼痛程度和炎性因子水平。结果治疗组总有效率为95.12%,明显高于对照组80.49%,差异有统计学意义(P<0.05)。治疗组的体温恢复时间、腮腺消肿时间、颈抵抗消失时间、嗜睡消失时间均明显短于对照组,差异有统计学意义(P<0.05)。治疗后,两组患儿的VAS评分明显低于治疗前(P<0.05),以治疗组患儿降低的更明显,差异有统计学意义(P<0.05)。在治疗后,两组患儿的白介素-4(IL-4)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均显著降低(P<0.05);治疗后治疗组的IL-4、IL-8、TNF-α水平比对照组低,差异有统计学意义(P<0.05)。结论喜炎平注射液联合注射用更昔洛韦能有效提高流行性腮腺炎的临床疗效,减轻患儿的临床症状和疼痛程度,抑制炎性因子分泌,具有一定的临床研究价值。

Objective To investigate the clinical effect of Xiyanping Injection combined with Ganciclovir for injection in treatment of mumps in children.Methods Children(82 cases)with mumps in Tianjin Baodi District People’s Hospital from March 2017 to September 2019 were divided into control group(41 cases)and treatment group(41 cases)according to the random number table method.Children in the control group were iv administered with Ganciclovir for injection,5 mg/kg,once per 12 h.Children in the treatment group were iv administered with Xiyanping Injection on the basis of the control group,10 mg/(kg?d).Patients in two groups were treated for 7 d.After treatment,the clinical efficacy was evaluated,and the improvement of clinical symptoms,degree of pain,and levels of inflammatory factors in two groups were compared.Results The total effective rate in the treatment group(95.12%)was significantly higher than that(80.49%)of the control group(P<0.05).After treatment,the body temperature recovery time,parotid detumescence time,neck resistance disappearance time,and drowsiness disappearance time between two groupsin the treatment group were shorter than those in the control group(P<0.05).After treatment,the VAS scores in two groups were significantly decreased(P<0.05),and the VAS scores in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of IL-4,IL-8,and TNF-αin two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the levels of IL-4,IL-8,and TNF-αin the treatment group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).Conclusion Xiyanping Injection combined with Ganciclovir for injection can effectively improve the clinical efficacy of mumps in children,relieve the clinical symptoms and pain of children,and inhibit the secretion of inflammatory factors,which has a certain clinical application value.