虎力散胶囊联合对乙酰氨基酚治疗风湿寒性关节痛的疗效观察

Clinical observation of Hulisan Capsules combined with paracetamol in treatment of rheumatic-cold arthralgia

目的探讨虎力散胶囊联合对乙酰氨基酚片治疗风湿寒性关节痛的临床疗效。方法选取2018年5月-2019年5月在上海市闵行区中西医结合医院治疗的86例风湿寒性关节痛患者,根据用药的差别分为对照组(43例)和治疗组(43例)。对照组口服对乙酰氨基酚片,0.5g/次,3次/d;治疗组在对照组基础上口服虎力散胶囊,0.3g/次,2次/d。两组患者均经5 d治疗。观察两组患者临床疗效,同时比较治疗前后两组患者中医症候积分及视觉模拟量表(VAS)评分、GQOLI-74和LKSS评分。结果治疗后,对照组临床有效率为81.40%,显著低于治疗组的97.67%,两组比较差异有统计学意义(P<0.05)。经治疗,两组患者中医症候积分均显著下降(P<0.05),且治疗组比对照组降低更明显(P<0.05)。经治疗,两组患者VAS评分显著下降(P<0.05),而GQOLI-74和LKSS评分均显著升高(P<0.05),且治疗组这些评分明显好于对照组(P<0.05)。结论虎力散胶囊联合对乙酰氨基酚片治疗风湿寒性关节痛可有效改善患者临床症状,减轻患者疼痛,促进患者关节功能、生活质量改善。

Objective To explore the clinical effect of Hulisan Capsules combined with Parecetamol Tablets in treatment of rheumatic-cold arthralgia. Methods Patients(86 cases) with rheumatic-cold arthralgia in Shanghai Minhang District TCMIntegrated Hospital from May 2018 to May 2019 were divided into control(43 cases) and treatment(43 cases) groups based on different treatments. Patients in the control group were po administered with Parecetamol Tablets, 0.5 g/time, three times daily. Patients in the treatment group were po administered with Hulisan Capsules on the basis of the control group, 0.3 g/time, twice daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the TCM syndrome scores, the VAS, GQOLI-74 and LKSS scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the TCM syndrome scores in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the VAS scores in two groups were significantly decreased(P < 0.05), but the GQOLI-74 and LKSS scores were significantly increased(P < 0.05), and these scores in the treatment group were significantly better than those in the control group(P < 0.05). Conclusion Hulisan Capsules combined with Parecetamol Tablets in treatment of rheumatic-cold arthralgia can effectively improve the clinical symptoms, alleviate the pain and promote the improvement of joint function and quality of life.