胃癌前病变患者胃蛋白酶原、促胃液素-17水平变化及幽门螺杆菌感染情况

Changes of pepsinogen and gastrin-17 and Helicobacter pylori infection in patients with pregastric cancer

目的研究胃癌前病变患者胃蛋白酶原、促胃液素-17及幽门螺杆菌(H.pylori)感染情况变化。方法试验组患者选取2017年8月至2018年8月间于我院进行治疗的100例胃癌前病变患者,对照组选取来我院体检中心进行体检的健康人员60例,对比两组人群胃蛋白酶原、促胃液素-17及H.pylori感染情况变化。结果试验组PGI(57.45±11.52)、PGII(8.65±1.75)、PGR(5.89±1.26)和促胃液素-17(8.05±1.45)水平显著低于对照组(均P<0.05);试验组H.pylori感染率81.00%显著高于对照组感染率41.67%,差异有统计学意义(P<0.05)。结论胃癌前病变患者PGI、PGII、PGR和促胃液素-17水平较低,并且H.pylori感染率高,患病与H.pylori感染有一定关系,胃蛋白酶原、促胃液素-17和H.pylori感染率对胃癌前病变临床诊断有重要作用,能够作为胃癌前病变患者筛查参考指标。

Objective To study the changes of pepsinogen, gastrin-17 and H. pylori infection in patients with pregastric cancer. Methods A total of 100 patients with pregastric cancer treated in our hospital from August 2017 to August 2018 were selected as the observation group, and 60 healthy examinees in the physical examination center of our hospital were selected as the control group. The changes of pepsinogen, gastrin-17 and H. pylori infection were compared between groups. Results The levels of PGI, PGII, PGR and gastric juice-17 in the observation group were significantly lower than in the control group(all P<0.05), while the infection rate of H. pylori in the observation group was significantly higher than that in the control group(P<0.05). Conclusion The levels of PGI, PGII, PGR and gastric juice-17 of patients with pregastric cancer are low, while the H. pylori infection rate is high, suggesting a relationship between the illness and H. pylori infection. Pepsin, gastric juice-17 and H. pylori infection have important significance for the clinical diagnosis of pregastric cancer lesion, which may be used as a reference index for the screening of pregastric cancer.