质子泵抑制剂对慢性肝病患者肠道微生态的影响

The effect of proton pump inhibitors on intestinal microbiota of patients with chronic liver disease

目的探究质子泵抑制剂(PPIs)对慢性肝病患者肠道微生态的影响。方法选取郑州市第六人民医院2018年12月至2019年3月诊断及拟行PPIs治疗的慢性肝病患者31名,使用奥美拉唑进行治疗,20 mg/次,2次/d,疗程4周,检测治疗前后肠道菌群的构成。结果治疗前后患者肠道菌群构成差异显著:治疗后患者肠道菌群在Shannon指数(4.61±0.62 vs 5.01±0.83;t=2.889,P=0.005)、Simpson指数(0.89±0.09 vs 0.95±0.11;t=3.159,P=0.002)显著低于治疗前;治疗前患者肠道菌群中Coriobacteriaceae、Eggerthella、Ruminococcus、Anaerotruncus、Dorea、Turicibacter、Paraprevotella的相对丰度显著高于治疗后,治疗后肠道菌群中Veillonellaceae、Campylobacter、Haemophilus、Streptococcus、Streptococcaceae、Lactobacillus、Lactobacillaceae的相对丰度显著高于治疗前(均P<0.05)。结论PPIs可改变慢性肝病患者肠道菌群的构成。

Objective To explore the effect of proton pump inhibitors(PPIs)on intestinal microbiota of patients with chronic liver disease. Methods Thirty-one patients with chronic liver disease from December 2018 to March 2019 were treated with PPIs in our hospital.Omeprazole was administered at the dose of 20 mg bid for 4 weeks;the intestinal flora was detected before and after treatment. Results There were significant differences in the composition of flora before and after treatment.The Shannon index(4.61±0.62 vs 5.01±0.83;t=2.889,P=0.005)and Simpson index(0.89±0.09 vs 0.95±0.11;t=3.159,P=0.002)after treatment were significantly lower than those before treatment.The relative abundances of Coriobacteriaceae,Eggerthella,Ruminococcus,Anaerotruncus,Dorea,Turicibacter and Paraprevotella before treatment were significantly higher,while those of Veillonellaceae,Campylobacter,Haemophilus,Streptococcus,Streptococcaceae,Lactobacillus and Lactobacillaceae after treatment were significantly higher(all P<0.05). Conclusion PPIs can alter the composition of intestinal flora in patients with chronic liver disease.