根据“肠-肾轴”理论治疗慢性肾脏病的研究进展

Research progress in the treatment of chronic kidney disease based on the theory of "intestinal-kidney axis"

有研究报道在慢性肾脏病的发生发展过程中可发现一系列肠道变化,并有学者用"肠-肾轴"理论阐述肾脏病中肠道的变化以及疾病过程中肾脏与肠道之间的联系,提示调节肠道菌群或可成为治疗慢性肾脏病的新方法。本文根据"肠-肾轴"理论,综述了在慢性肾脏病发展过程中肠道出现的变化,如肠内代谢物异常、肠道损伤以及肠道菌群失调等。以慢性肾脏病发生发展过程中肠道的异常变化为治疗切入点,总结了以大黄为主的中药在调节肠道功能、修复肠道屏障、纠正肠道代谢物异常等方面具有的显著疗效,为治疗慢性肾脏病及减少并发症等提供新的治疗思路和新方法。

Studies have reported that a series of intestinal changes can be observed during the development of chronic kidney disease, and some scholars have proposed the "intestinal-kidney axis" theory to explain the changes in the intestinal tract in kidney disease and the relation between kidney and intestine during the disease process, which suggests that regulation of intestinal flora may be a new treatment for chronic kidney disease. In this paper, the changes in intestinal tract during the development of chronic kidney disease, such as intestinal metabolite abnormalities, intestinal damage and intestinal flora imbalance, are reviewed based on the "intestinal-kidney axis" theory. With abnormal changes of intestinal tract in the disease process as the entry point of treatment, the significant effects of traditional Chinese medicine based on rhubarb in regulating intestinal function, repairing intestinal barrier and correcting intestinal metabolite abnormalities are summarized in order to provide new treatment ideas and methods to reduce complications.