NAD^+与细胞衰老

NAD^+ and Cellular Senescence

烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD^+)作为糖酵解、三羧酸循环和氧化磷酸化中关键酶的辅助因子,参与了细胞的物质代谢、能量合成、损伤DNA的修复等多种生理病理过程。近年来越来越多的研究发现,细胞内NAD^+水平在机体或细胞衰老过程中呈明显下降趋势,而补充NAD^+能延缓细胞/机体的衰老,使NAD^+及其前体物质在细胞衰老中的作用受到广泛关注。该文就NAD^+及其前体物质与细胞代谢、衰老的关系及相关分子机制研究的最新进展进行综述,以期深入认识NAD^+与细胞衰老的内在联系,为细胞衰老相关的基础及应用研究提供理论参考。

NAD^+(nicotinamide adenine dinucleotide)is an essential cofactor of key enzymes in glycolysis,TCA(tricarboxylic acid)cycle and oxidative phosphorylation,which participates in many physiological and pathological activities,such as cellular metabolism,energy synthesis,and repair of injured DNA.In recent years,studies have found that NAD^+ shows a downward trend during the body or cell senescence,whlie replenishment of NAD^+ or its precursors significantly delayed cell senescence and improved lifespan.Therefore,the application of NAD^+ and its precursors has attracted widespread attention.In this review,we will briefly summarize the current research progresses about the relationship between the NAD^+ and its precursors and cellular metabolism,senescence and the involved mechanisms.A better understanding of their relationship will provide an important reference for basic and applied studies on cellular senescence.