miRNAs表达异常与宫颈癌发生发展关系的研究进展

Research Progress on Abnormal Expression of miRNAs and Development of Cervical Cancer

宫颈癌(cervical cancer,CC)是严重危害女性健康的疾病之一,具有高的发病率和死亡率。微小RNA(miRNAs)是一类小分子非编码RNA,通过转录后沉默来调控基因表达。表达异常的miRNAs主要通过调控细胞周期、细胞凋亡以及多种信号通路的方式参与宫颈癌的发生发展。该文就近年来miRNAs在宫颈癌发生发展、诊断、治疗和预后评估等方面的研究进展做一综述,以寻求对宫颈癌的防治提供新思路。

CC(cervical cancer)is one of the diseases that seriously endanger women’s health,with high morbidity and mortality.miRNAs(microRNAs)are a class of small non-coding RNAs that regulate gene expression through post-transcriptional silencing.Abnormally expressed miRNAs are involved in the development of cervical cancer mainly by regulating cell cycle,apoptosis and various signaling pathways.In this paper,the research progress of miRNAs in the progress,diagnosis,treatment and prognosis of cervical cancer in recent years is reviewed to seek new ideas for the prevention and treatment of cervical cancer.