重复经颅磁刺激治疗抑郁症的神经机制探索及疗效预测研究进展

Neural mechanism and efficacy prediction of repetitive transcranial magnetic stimulation in treatment of depression

介绍了抑郁症的患病机制和临床治疗措施,重点从神经机制和疗效预测方面分析了近年来重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗抑郁症的研究进展,分析了rTMS主要是通过改善大脑网络异常连接来治疗抑郁症,同时发现了亚属扣带回(subgenual cingulate gyrus,SCG)皮层的基线连接对rTMS疗效预测具有重要作用。总结了rTMS抗抑郁治疗研究中存在的不足,指出了未来应着重于在多模式影像预测因子选择、rTMS参数设置和脑部刺激靶点选取等方面进行深入研究,为探索rTMS的抗抑郁机制和改善治疗效果提供了新的思路。

The pathogenesis and clinical treatment measures of depression were briefly introduced,and the research progress of repetitive transcranial magnetic stimulation(rTMS)in the treatment of depression was mainly analyzed from the aspects of neural mechanism and efficacy prediction in recent years.The treatment of depression using rTMS mainly by improving the abnormal connection of brain network was systematically introduced,and it's found that the baseline connection of subgenual cingulate gyrus(SCG)cortex played an important role in the prediction of therapeutic effect of rTMS.At last,the shortcomings of the research on the antidepressant therapy of rTMS were summarized,then it's pointed out that in the future,the selection of multimodal imaging predictors,rTMS parameter settings and the selection of brain stimulation targets should be emphasized so as to provide a new way to explore the antidepressant mechanism and improve the therapeutic effect of rTMS.