阿戈美拉汀对甲基苯丙胺依赖者脱毒后睡眠障碍的干预研究

The clinical effect of agometine on sleep disorder after detoxification in methamphetamine-dependent patients

目的:观察阿戈美拉汀对甲基苯丙胺依赖者脱毒后睡眠障碍的临床疗效。方法:选取91例甲基苯丙胺依赖者,脱毒后随机分为治疗组与对照组,治疗组给予阿戈美拉汀治疗,对照组给予安慰剂治疗。对所有人员采用匹兹堡睡眠质量指数量表进行评价并应用整夜多导睡眠监测。结果:(1)治疗4周后,治疗组匹兹堡睡眠质量指数量表评分显著提高,明显高于对照组(P<0. 01)。(2)治疗4周后,治疗组的觉醒次数、觉醒时间、睡眠潜伏期、N1比例、N2比例、N3比例、觉醒睡眠比显著改善,与治疗前相比,差异有显著性意义(P<0.01),改善明显优于对照组(P<0.01);REM潜伏期、REM睡眠时间、REM活动度、REM密度、REM强度和入组时无明显改善(P>0.05)。而对照组仅在总睡眠时间较入组时延长(P<0. 01)、睡眠潜伏期低于入组时(P<0. 01),睡眠效率高于入组时(P<0. 01);其余指标和入组时相比无明显改善(P>0.05)。结论:阿戈美拉汀可以显著改善甲基苯丙胺依赖者的睡眠质量。

Objective:To observe the clinical effect of agometine on sleep disorder after detoxification in methamphetamine-dependent patients. Methods:91 methamphetamine-dependent patients were randomly divided into treatment group and control group after detoxification. The treatment group was treated with agometine, and the control group was treated with placebo. All participants were assessed using the Pittsburgh sleep quality index and monitored with overnight polysomnography. Results:(1) After 4 w treatment, the Pittsburgh sleep quality index score of the treatment group was significantly improved, significantly higher than that of the control group(P<0.01).(2) After 4 w treatment, the number of awakenings, wakefulness time, sleep latency, N1 ratio, N2 ratio, N3 ratio and wakenings and sleep ratio of the treatment group were significantly improved, with significant difference compared with that before treatment(P < 0.01), and the improvement was significantly better than that of the control group(P<0.01). There was no significant improvement in REM latency, REM sleep time, REM activity, REM density, REM intensity and group entry(P>0.05). However, the total sleep time of the control group was longer than that of the group(P < 0.01), the sleep latency was lower than that of the group(P<0.01), and the sleep efficiency was higher than that of the baseline(P < 0.01). The other indicators showed no significant improvement compared with the group(P>0.05). Conclusion:Agometine can significantly improve the sleep quality of methamphetamine-dependent patients.