金果胃康胶囊治疗胃黏膜上皮内瘤变患者的临床研究

Clinical trial of Weikang Capsule in the treatment of patients with gastric intraepithelial neoplasia

目的观察金果胃康胶囊对胃黏膜上皮内瘤变患者治疗效果以及对血清胃泌素17(G-17)、胃蛋白酶原(PG)和血管活性肠肽(VIP)水平的影响。方法选取2017年8月至2018年8月陕西中医药大学附属医院就诊的胃黏膜上皮内瘤变患者83例作为试验组,选取同期体检健康者83例为对照组。用酶联免疫吸附法检测血清G-17、PG和VIP水平。结果试验组的总有效率为87.50%,治疗后与治疗前相比,差异有统计学意义(P<0.05)。对照组和治疗前、后试验组的G-17水平分别为(4.52±0.90),(2.06±0.41)和(3.77±0.75)μg·L^-1;对照组和治疗前、后试验组的PG水平分别为(119.95±23.99),(95.46±19.09)和(114.58±22.92)μg·L^-1;对照组和治疗前、后试验组的VIP水平分别为(9.46±1.89),(16.17±3.23)和(8.16±1.63)μg·L^-1。上述指标:试验组与对照组相比,差异均有统计学意义(均P<0.05);试验组在治疗后与治疗前相比,差异均有统计学意义(均P<0.05)。结论金果胃康胶囊治疗胃黏膜上皮内瘤变疗效显著,其作用机制可能与上调G-17、PG表达和下调VIP表达有关。

Objective To investigate the clinical trial of Weikang Capsule in the treatment of patients with gastric intraepithelial neoplasia and the effect on the levels of serum gastrin 17(G-17),pepsinogen(PG)and vasoactive intestinal peptide(VIP).Methods Eighty patients with gastric mucosal intraepithelial neoplasia from August 2017 to August 2018 were selected as the treatment group,and 83 healthy persons were selected as the control group.The levels of G-17,PG and VIP in serum were detected by enzyme-linked immunosorbent assay.Results The total effective rate of the treatment group was 87.50%.There was statistical significance between after treatment and before treatment of the treatment group(P<0.05).The serum G-17 in control group,treatment group of before and after treatment were(4.52±0.90),(2.06±0.41),(3.77±0.75)μg·L^-1;the serum PG levels in control group,treatment group of before and after treatment were(119.95±23.99),(95.46±19.09),(114.58±22.92)μg·L^-1;the serum VIP levels in control group,treatment group of before and after treatment were(9.46±1.89),(16.17±3.23),(8.16±1.63)μg·L^-1.There was statistical significance of the factors between treatment group and control group before treatment(all P<0.05);there was statistical significance of the factors between after treatment and before treatment of the treatment group(all P<0.05).Conclusion Weikang Capsule can increase the serum G-17 and PG levels and decrease the VIP level.The three indexes can be used as biological indicators to evaluate the therapeutic effect of Weikang Capsule.