乙醛脱氢酶1A1和表皮生长因子受体在胃癌中的表达及临床意义

Expression and significance of aldehyde dehydrogenase1A1 and epidermal growth factor receptor in gastric adenocarcinoma

目的研究乙醛脱氢酶1A1(ALDH1A1)和表皮生长因子受体(EGFR)在胃腺癌表达情况及其与临床病理特点的关系。方法用免疫组织化学方法检测98例患者胃癌组织、对应癌旁组织和52例正常胃黏膜组织中ALDH1A1和EGFR表达情况。结果ALDH1A1在癌旁组织和胃癌组织中阳性率分别为10.2%(10例/98例)和43.9%(43例/98例),两者比较差异有统计学意义(P<0.05)。EGFR在癌旁组织和胃癌组织中阳性率分别为13.3%(13例/98例)和52.0%(51例/98例),两者比较差异有统计学意义(P<0.05)。存在远处转移患者胃癌组织ALDH1A1蛋白表达为56.8%(25例/44例),无远处转移患者为33.3%(18例/54例),两者比较差异有统计学意义(P<0.05)。存在远处转移患者胃癌组织EGFR蛋白表达为70.4%(31例/44例),无远处转移患者为37.0%(20例/54例),两者比较差异有统计学意义(P<0.05)。结论ALDH1A1和EGFR在胃腺癌组织内异常表达,且与胃癌的发生与发展有关。

Objective To investigate the expression of aldehyde dehydrogenase 1 A1(ALDH1 A1)and epidermal growth factor receptor(EGFR)in human gastric cancer tissues,and analyze its relationship with clinicopathological characteristics.Methods The expression of ALDH1 A1 and EGFR protein in gastric cancer tissues and the paired adjacent normal tissues from 98 patients and 52 normal was detected by immunohistochemistry.Results The ALDH1 A1 protein in gastric cancer and paracancerous tissue 10.2%(10 cases/98 cases)and 43.9%(43 cases/98 cases),comparison between gastric cancer and paracancerous tissue,the difference was significantly(P<0.05).EGFR protein in gastric cancer and paracancerous tissue was 13.3%(13 cases/98 cases)and 52.0%(51 cases/98 cases),comparison between gastric cancer and paracancerous tissue,the difference was significantly(P<0.05).Comparison between the expression of ALDH1 A1 in distant metastasis with 56.8%(25 cases/44 cases)and no distant metastasis with 33.3%(18 cases/54 cases),the difference was significantly(P<0.05).Comparison between the expression of EGFR in distant metastasis with 70.4%(31 cases/44 cases)and no distant metastasis with 37.0%(20 cases/54 cases),the difference was significantly(P<0.05).Conclusion ALDH1 A1 and EGFR were up-regulated in gastric cancer.ALDH1 A1 and EGFR may be promotes the development of gastric cancer.