剥脱综合征与系统性疾病的相关性

Relationship between exfoliation syndrome and systemic diseases

剥脱综合征(exfoliation syndrome,XFS)是一种年龄相关性疾病,其片状白色絮状物沉积于眼前房及眼内其他组织可导致继发性青光眼。流行病学研究表明,XFS会增加冠状动脉疾病、高血压、脑血管疾病、外周血管疾病、肾动脉狭窄、感觉神经性听力丧失等全身疾病的风险。虽然血管壁弹性纤维合成异常、血清抗磷脂抗体水平升高、氧化应激增加、内皮功能障碍和高同型半胱氨酸血症均与XFS血管并发症的发生有关,但其确切的发病机制尚不清楚。

Exfoliation syndrome(XFS)is a complex age-related disease in which flaky white floes deposit in the anterior chamber of the eye and other tissues in the eye,and cause glaucoma.Epidemiological studies showed that XFS increases risk of coronary artery disease,hypertension,cerebrovascular disease,abdominal aortic aneurysm,peripheral vascular disease,sensorineural hearing loss.The exact mechanism underlying the development of vascular complications in XFS remains poorly understood,although abnormal elastic fiber synthesis in vessel walls,elevated serum antiphospholipid antibody levels,increased oxidative stress,endothelial dysfunction and hyperhomocysteinemia are all hypothesized to play contributory roles.