摘要
糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病性微血管病变中最重要的表现,是一种具有特异性改变的眼底病变,糖尿病的严重并发症之一。DR具体发病机制仍不明确,目前尚无有效的治疗措施。斑马鱼作为一种模型动物,能够通过一定的处理很好地模拟糖尿病及DR的发病过程,如DR早期眼底微血管瘤样改变。同时,斑马鱼也可以为新研发药物的治疗效果提供可靠的参考。
Diabetic retinopathy(DR)is the most important manifestation of diabetic microangiopathy.It is a kind of fundus lesion with specific changes,one of the serious complications of diabetes.The specific pathogenesis of DR remains unclear,and there are no effective treatments.As a model animal,zebrafish can well simulate the pathogenesis of diabetes and DR through certain treatments.Some scholars have found that zebrafish can simulate early fundus aneurismlike changes in DR.At the same time,zebrafish can also provide a reliable reference for the therapeutic effects of newly developed drugs.
作者
李乐乐
朱曼辉
涂园园
杨楷文
刘东
石运伟
桑爱民
Li Lele;Zhu Manhui;Tu Yuanyuan;Yang Kaiwen;Liu Dong;Shi Yunwei;Sang Aimin(Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226000,China;Lixiang Eye Hospital of Soochow University,Suzhou 215008,China;Nantong University Xinglin College,Nantong 226000,China;Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Nantong 226000,China)
出处
《国际眼科纵览》
2020年第1期63-67,共5页
International Review of Ophthalmology
基金
江苏省研究生科研与实践创新计划(CJCX180829)。
