武汉市健康婴儿鼻咽部肺炎链球菌及流感嗜血杆菌定植状况的调查

Investigation on colonization status of Streptococcus pneumoniae and Haemophilus influenzae in healthy infants in Wuhan

目的了解武汉市健康婴儿鼻咽部肺炎链球菌、流感嗜血杆菌的定植状况。方法抽取6个预防接种门诊,采集受种健康婴儿鼻咽部标本,进行肺炎链球菌、流感嗜血杆菌的培养。结果998名受检健康婴儿鼻咽部肺炎链球菌、流感嗜血杆菌携带率为18.84%、17.54%,6月龄以内的肺炎链球菌、流感嗜血杆菌的携带率为15.79%、14.39%,7~12月龄的肺炎链球菌、流感嗜血杆菌的携带率为22.90%、21.73%,差异有统计学意义(Sp:χ2=5.60,P=0.02;Hi:χ2=8.98,P=0.00);城区、郊区肺炎链球菌携带率为18.08%、19.78%,流感嗜血杆菌携带率为17.18%、17.98%,差异无统计学意义(Sp:χ2=0.47,P=0.50;Hi:χ2=0.11,P=0.74);月龄与Sp、Hi携带率的相关系数(r值)为0.98、0.96。结论武汉市健康婴儿月龄与肺炎链球菌、流感嗜血杆菌携带率呈高度线性正相关。

Objective To understand the colonization status of Streptococcus pneumoniae and Haemophilus influenzae in nasopharynx of healthy infants in Wuhan.Methods Six vaccination clinics were randomly selected,and the nasopharyngeal specimens of healthy infants were collected and cultured for Streptococcus pneumoniae and Haemophilus influenza.Results The carrying rate of Streptococcus pneumoniae and Haemophilus influenzae in 998 healthy infants was 18.84%and 17.54%,respectively.The carrying rate of Streptococcus pneumoniae and Haemophilus influenzae within 6 months of age was 15.79%and 14.39%,and the carrying rate of Streptococcus pneumoniae and Haemophilus influenzae at 7-12 months old was 22.90%and 21.73%,respectively.The difference was statistically significant(Sp:χ2=5.60,P=0.02;Hi:χ2=8.98,P=0.00);The carrying rate of Streptococcus pneumoniae in urban and suburban areas was 18.08%and 19.78%,respectively,and the Haemophilus influenzae carrying rate was 17.18%and 17.98%,respectively.The differences were not statistically significant(Sp:χ2=0.47,P=0.50;Hi:χ2=0.11,P=0.74).The correlation coefficient(r value)of the age of the month and the carrying rate of sp and hi was 0.98 and 0.96,respectively.Conclusion The age of healthy infants in Wuhan was highly linearly and positively correlated with the carrying rate of Streptococcus pneumoniae and Haemophilus influenza.