早期综合干预对早产儿发育影响的临床研究

Clinical research of early comprehensive intervention for development of premature infant

目的评价早期综合干预对早产儿(包括试管婴儿)身体及智能发育的影响。方法以2016年6月至2018年6月在大连市妇幼保健院治疗的早产儿111例作为研究对象,研究组给予一对一健康宣教、运动训练、营养指导及康复治疗等综合干预,对照组给予常规健康指导,出现发育异常时给予康复治疗。随访并收集两组早产儿3、6、12个月的体质量、身长、头围和婴幼儿智能发育测试量表(CDCC)评分。结果身体发育:研究组3、6、12个月的体质量、3、6个月的身长及头围发育较对照组好[体质量:(4.72±0.19)kg比(4.34±0.29)kg、(6.49±0.37)kg比(6.25±0.41)kg、(9.58±1.15)kg比(8.76±0.92)kg;身长:(59.63±5.51)cm比(56.29±5.86)cm、(65.09±5.94)cm比(62.36±6.20)cm;头围:(37.71±1.77)cm比(35.90±1.48)cm、(43.18±1.96)cm比(41.82±2.61)cm],差异有统计学意义(P<0.05或<0.01)。智能发育:研究组3、6、12个月智力发育指数(MDI)和精神运动发育指数(PDI)评分较对照组高[MDI评分:(84.49±9.78)分比(80.58±10.40)分、(89.65±13.21)分比(83.24±17.66)分、(96.03±15.43)分比(89.71±17.85)分;PDI评分:(82.68±5.35)分比(79.43±7.21)分、(86.34±8.33)分比(82.51±9.67)分、(94.86±10.27)分比(90.32±11.65)分],差异有统计学意义(P<0.05)。结论早期综合干预可以对早产儿(包括试管婴儿)身体及智能发育起到促进作用,值得推广。

Objective To research the clinical effect of early comprehensive intervention for physical and intelligence development of premature infant(test-tube baby).Methods One hundred and eleven premature infant in Dalian Municipal Women and Children′s Medical Center from June 2016 to June 2018 were enrolled.Study group(57 cases)received comprehensive intervention including health education,exercise training,nutrition guidance and rehabilitation therapy,and control group(54 cases)received health education.The weight,height,head circumference and CDCC score of two groups were analyzed in 3,6 and 12 month.Results Physical development:the weight[3 month:(4.72±0.19)kg vs.(4.34±0.29)kg;6 month:(6.49±0.37)kg vs.(6.25±0.41)kg;12 month:(9.58±1.15)kg vs.(8.76±0.92)kg]and height[3 month:(59.63±5.51)cm vs.(56.29±5.86)cm;6 month:(65.09±5.94)cm vs.(62.36±6.20)cm]in 3,6 and 12 month,and head circumference in 3 and 6 month[3 month:(37.71±1.77)cm vs.(35.90±1.48)cm;6 month:(43.18±1.96)cm vs.(41.82±2.61)cm]of study group were higher than those in control group,and all difference had statistical significant(P<0.05).Intelligence development:the MDI[3 month:(84.49±9.78)scores vs.(80.58±10.40)scores;6 month:(89.65±13.21)scores vs.(83.24±17.66)scores;12 month:(96.03±15.43)scores vs.(89.71±17.85)scores]and PDI score of study group was higher than that in control group in 3,6 and 12 month[3 month:(82.68±5.35)scores vs.(79.43±7.21)scores;6 month:(86.34±8.33)scores vs.(82.51±9.67)scores;12 month:(94.86±10.27)scores vs.(90.32±11.65)scores](P<0.05).Conclusions Early comprehensive intervention has a good clinical efficacy for physical and intelligence development of premature infant(test-tube baby)and is worthy of popularizing and applying.