中西医结合治疗老年帕金森病心脾两虚型失眠患者的疗效

Effect of integrated traditional Chinese and western medicine in Parkinson′s disease patients over age 60 with insomnia differentiated by heart-spleen deficiency

目的探讨60岁以上心脾两虚型失眠老年帕金森病患者的中西医结合综合治疗效果。方法选取2015年3月—2016年3月就诊的100例心脾两虚型失眠老年帕金森病患者进行研究。通过随机数表法分为治疗组和对照组,各50例。对照组给予地西泮进行治疗,治疗组在对照组的基础上加用归脾汤,均连续治疗1个月。观察两组患者治疗前后入睡时间、睡眠时间、夜间觉醒次数,比较Epworth困倦量表(ESS)评分和匹兹堡睡眠质量指数量表(PSQI)评分,比较治疗后临床疗效及不良反应。结果治疗后两组患者睡眠质量与治疗前比较均得到改善(P<0.05),且治疗组入睡时间,睡眠时间,夜间觉醒次数均优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后两组患者嗜睡评分、睡眠质量指数均优于治疗前(P<0.05),且治疗组嗜睡评分、睡眠质量指数均优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后治疗组不良反应总发生率为4.00%,明显优于对照组16.00%,两组比较差异有统计学意义(P<0.05)。治疗后治疗组总有效率94.0%优于对照组72.0%,两组比较差异有统计学意义(P<0.05)。结论在60岁以上心脾两虚失眠老年帕金森患者中给予中西医治疗的效果优异,值得应用推广。

Objective To investigate the effect of integrated traditional Chinese and western medicine on Parkinson′s Disease(PD)patients over age 60 with insomnia differentiated by heart-spleen deficiency.Methods A total of 100 PD patients with insomnia differentiated by heart-spleen deficiency admitted to our hospital from March,2015 to March,2016 were included and randomly divided into the treatment group and the control group by using random number table,with 50 cases in each group.The control group was given diazepam,while the treatment group was additionally given Guipi Decoction.The treatment course was one month.Time of falling asleep,sleep duration,number of awakenings,the Epworth sleepiness scale(ESS)score,and the Pittsburgh Sleep Quality Index(PSQI),and adverse reactions in both groups were compared after treatment.Results After treatment,the sleep quality in both groups was improved(P<0.05),and the improvement of the time of falling asleep,sleep duration,and number of awakenings in the treatment group was more significant than in the control group,with significance(P<0.05).After treatment,the ESS score and PSQI in both groups were improved(P<0.05),and the improvement in the treatment group was more significant than in the control group,with significance(P<0.05).After treatment,the incidence of adverse reactions in the treatment group was 4.00%,which was significantly lower than that(16.00%)in the control group,with significance(P<0.05).After treatment,the total effective rate in the treatment group was 94.0%,which was significantly higher than that(72.0%)in the control group,with significance(P<0.05).Conclusion The effect of integrated traditional Chinese and western medicine on insomnia of heart-spleen deficiency pattern in patients with Parkinson′s Disease(PD)over age 60 is significant and worthy of application.