重症急性胰腺炎的营养治疗

Nutritional Treatment of Severe Acute Pancreatitis

重症急性胰腺炎(severe acute pancreatitis,SAP)是一种预后不良且死亡率较高的疾病,营养支持治疗对SAP至关重要。较多的临床研究显示早期肠内营养对SAP是安全和有益的。而目前许多临床医生(特别是基层医疗单位医务者)仍然认为绝对禁食是标准治疗模式,这一错误理念可能会对病人造成伤害,该疾病治疗模式须予以纠正,应采用更合理的营养模式。本综述借鉴既往研究,分析SAP的生理、病理机制,为SAP的营养支持提供最新的实践依据及建议。

Severe acute pancreatitis(SAP)is a disease with poor prognosis and high mortality.Nutritional support therapy is critical for SAP,numerous clinical studies showing that early enteral nutrition is safe and beneficial for SAP.However,many clinicians(especially those in primary medical units)still believe that absolute fasting is the standard mode of treatment,which may cause harm to patients.The disease treatment mode should be corrected and more reasonable nutrition mode should be adopted.This review draws lessons on previous studies,analyzes the physiological and pathological mechanisms of SAP,and provides the latest practical basis and suggestions for nutritional support of SAP.