新型冠状病毒(COVID-19)精准药物设计--基于病毒感染人体细胞进程的初步探讨

Precise Drug Design for the Novel Coronavirus( COVID-19):A Preliminary Prediction on the Process of Virus Infection in Human Cells

针对新型冠状病毒(COVID-19)精准药物研发问题,围绕COVID-19感染人体细胞的基本步骤,如病毒表面蛋白结合人体细胞受体、病毒穿透细胞膜、病毒脱壳、病毒核酸释放与复制、病毒蛋白表达与成熟、新病毒装配等,预测针对这些环节设计小分子化合物、抗体或反义RNA片段等,进而抑制病毒关键分子如Spike蛋白、RdRp聚合酶、3CL水解酶及多种关键的RNA基因序列,最终达到精准治疗新型冠状病毒感染的目的。

In view of promoting the research and development of precision drugs for the novel coronavirus COVID-19,this paper focuses on the basic steps of COVID-19 infection in human cells,such as viral surface protein binding to human cell receptor,viral penetration into cell membrane,viral uncoating,release and replication of viral nucleic acids,expression and maturation of viral proteins,new virus assembly. Based on these steps,it is expected that small molecule compounds,antibodies or antisense RNA fragments could be designed to prevent the key viral molecules such as Spike protein,RdRp polymerase,3 CL hydrolase and a variety of key RNA genes,so as to achieve the goal of accurate treatment of COVID-19 infection.