“伏毒”与糖尿病性难愈溃疡发病关系的研究进展

Research progress on the relationship between‘lingering toxins’and diabetic non-healing ulcers

糖尿病性溃疡发病率高,难以愈合,威胁患者的肢体及生命健康,是临床中亟待解决的难题。“正虚伏毒”是中医传统的发病理论,“伏毒”导致糖尿病性溃疡难愈,晚期糖基化终末产物(AGEs)沉积及引发的多种病理改变是其可能的发病机制;祛腐生肌法是中医外科的经典治则,能够清除伏毒以促进糖尿病性溃疡愈合。基于中医“伏毒”理论探讨糖尿病性难愈溃疡的机制,将为中医传统发病学说——“伏毒”理论增加新的内涵,亦将为祛腐生肌中药治疗糖尿病性溃疡机制的研究带来新的思路。

Diabetic ulcer has a higher incidence and difficult to heal,may threat patients’limbs and life,which is the problem need to be solved urgently in clinic.Healthy-energy deficiency and lingering toxins is the pathogenesis theory of traditional Chinese medicine,‘lingering toxins’can lead to diabetic ulcers difficult to heal.AGEs accumulating and its multiple pathological changes are the possible pathogenesis.Qufu Shengji is a classic therapeutic principle of Chinese medicine surgery,it can clear lingering toxins to promote the healing of diabetic ulcers.The project will study the pathological mechanism of diabetic non-healing ulcers based on the theory of‘lingering toxins’,also will increase the new connotation for traditional Chinese medicine pathogenesis theory of lingering toxins,and also will bring a new ideas for the study of mechanism of Qufu Shengji traditional Chinese medicine treating diabetic ulcers.