基于“土壅木郁”探析非酒精性脂肪肝的痰湿体质分布研究

Exploration on the distribution of phlegm-dampness constitution of nonalcoholic fatty liver disease based on‘soil obstructed and wood obstructed’

目的:通过对非酒精性脂肪肝患者中医体质分布研究,并基于“土壅木郁”理论探讨非酒精性脂肪肝的中医发病机制,为临床辨证论治提供依据。方法:对涉及7个省份的12项研究中纳入的5945例非酒精性脂肪肝患者的中医体质类型进行Meta分析,以探究痰湿体质在该病中分布情况。结果:痰湿体质是非酒精性脂肪肝患者的最主要体质类型,此偏颇体质类型占患者群体总人数的比例为34%。结论:非酒精性脂肪肝的主要病机是“土壅木郁”痰湿内蕴,通过对体质进行调理对非酒精性脂肪肝的发生及转化具有重要的预防意义,可以更好地从“治未病”角度“未病先防”。

Objective:To study the distribution of TCM constitutions in patients with nonalcoholic fatty liver disease,and to explore the pathogenesis of nonalcoholic fatty liver disease in TCM based on the theory of‘soil obstructed by wood stagnation’,so as to provide evidence for clinical syndrome differentiation and treatment.Methods:A Meta-analysis was conducted on the TCM constitution types of 5945 non-alcoholic fatty liver patients included in 12 studies involving 7 provinces to explore the distribution of phlegm-dampness constitution in the disease.Results:Phlegm-dampness constitution was the most important constitution type in patients with nonalcoholic fatty liver disease,which accounted for 34%of the total number of patients.Conclusion:The main pathogenesis of nonalcoholic fatty liver disease is the phlegm-dampness connotation of‘soil obstructed by wood stagnation’.Through conditioning the constitution,it is of great significance to prevent the occurrence and transformation of nonalcoholic fatty liver disease,which can be better prevented from the perspective of‘treating the disease’.