孤儿核受体Nur77基因多态性与脓毒症易感性的关联研究

Association of orphan nuclear receptor Nur77 gene polymorphisms with susceptibility to sepsis

目的研究脓毒症患者与健康成人孤儿核受体Nur77基因多态性分布规律,并探讨其与脓毒症易感性的关系。方法选择207例脓毒症患者(脓毒症组)及210例健康体检者(对照组)作为研究对象。使用SNaPshot技术分析Nur77基因rs10876228、rs11169989、rs1283155、rs2242107位点基因型,比较两组Nur77基因位点多态性分布规律,探讨其与脓毒症易感性之间的关系。结果脓毒症组与对照组的Nur77基因rs10876228、rs11169989、rs1283155、rs2242107多态性位点的等位基因及基因型分布频率差异均无统计学意义(P>0.05)。结论Nur77基因多态性或许与脓毒症易感性无明显相关。

Objective To investigate the distribution of orphan nuclear receptors Nur77 polymorphisms in patients with sepsis and healthy adult subjects,and to explore its association with susceptibility to sepsis.Methods A total of 207 patients with sepsis(sepsis group)and 210 healthy subjects in physical examination(control group)were enrolled in the study.Genotypes of Nur77 gene in loci rs10876228,rs11169989,rs1283155 and rs2242107 were determined by a SNaPshot technique.Comparison of the distribution of Nur77 gene polymorphisms between sepsis group and control group was conducted,and the association of polymorphic genotypes with susceptibility to sepsis was evaluated.Results The distribution of allele and genotype frequencies of Nur77 gene polymorphism in loci rs10876228,rs11169989,rs1283155 and rs2242107 in sepsis group did not differ significantly from those in control group(P>0.05).Conclusion The Nur77 gene polymorphisms might not have obvious correlation with the susceptibility to sepsis.