磷酸奥司他韦治疗小儿流行性感冒对患儿血清C-反应蛋白及炎性因子的影响

Effect of oseltamivir phosphate on serum C-reactive protein and inflammatory factors in children with influenza

目的:探讨磷酸奥司他韦治疗小儿流行性感冒对患儿血清C-反应蛋白(CRP)及炎性因子的影响。方法:2017年10月-2019年3月收治流行性感冒患儿80例,随机分为两组,各40例,均常规对症处理。对照组口服利巴韦林治疗。观察组口服磷酸奥司他韦胶囊治疗。比较两组患儿疗效、治疗前后CRP和白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及用药不良反应。结果:观察组治疗总有效率明显高于对照组,观察组治疗后CRP、TNF-α、IL-6水平均显著低于对照组,观察组不良反应发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论:采用磷酸奥司他韦治疗流行性感冒患儿能取得比较理想的疗效,能显著改善炎性反应,安全性较高。

Objective:To explore the effect of oseltamivir phosphate on serum C-reactive protein and inflammatory factors in children with influenza.Methods:80 children with influenza were selected from October 2017 to March 2019,they were randomly divided into the two groups with 40 cases in each group,all of them were treated with routine symptomatic treatment.The control group was treated with ribavirin.The observation group was treated with oseltamivir phosphate capsule.The therapeutic effect,C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and adverse drug reactions were compared between the two groups.Results:The total effective rate of the observation group was significantly higher than that of the control group.After treatment,the CRP,TNF-α,IL-6 levels in the observation group was significantly lower than those in the control group,and the incidence of adverse reactions in the observation group was significantly lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Using oseltamivir phosphate in the treatment of children with influenza can achieve a better effect,which can significantly improve the inflammatory response,with high safety.