芍药甘草汤加减对急性胃溃疡胃黏膜保护作用的疗效评价

Evaluation of the protective effect of modified shaoyaogancao decoction on gastric mucosa of acute gastric ulcer

目的:研究芍药甘草汤加减对急性胃溃疡胃黏膜保护作用的疗效。方法:2018年5月-2019年4月收治急性胃溃疡患者92例,随机分为两组,各46例。对照组接受常规治疗;观察组在常规治疗的基础上联合芍药甘草汤加减治疗。比较两组临床疗效及治疗前、后胃黏膜EGF和EGFR表达水平。结果:观察组治疗后治疗总有效率明显高于对照组,两组患者治疗后胃黏膜EGF和EGFR表达水平均明显升高,且观察组治疗明显优于对照组,差异均有统计学意义(P<0.05)。结论:急性胃溃疡患者在常规治疗基础上联合芍药甘草汤加减治疗能显著提高治疗总有效率并能显著增强对胃黏膜的保护作用,临床效果显著。

Objective:To study the protective effect of modified shaoyaogancao decoction on gastric mucosa of acute gastric ulcer.Methods:92 patients with acute gastric ulcer were selected from May 2018 to April 2019,they were randomly divided into the two groups with 46 cases in each group.The control group received routine treatment,the observation group was treated with sshaoyaogancao decoction on the basis of routine treatment.The expression of EGF and EGFR in gastric mucosa before and after treatment and the treatment effect were compared.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group,and the expression level of EGF and EGFR in the gastric mucosa of the two groups was significantly higher,and the treatment of the observation group was significantly better than that of the control group,the differences were statistically significant(P<0.05).Conclusion:On the basis of routine treatment,patients with acute gastric ulcer combined with shaoyaogancao decoction can significantly improve the total effective rate and significantly enhance the protective effect on gastric mucosa,and the clinical effect is significant.