胰岛素抵抗在相关皮肤病中的研究进展

Insulin Resistance and Skin Diseases

胰岛素抵抗是指机体胰岛素促进葡萄糖摄取和利用的效率下降的病理性反应。近年发现一些皮肤病与代谢综合征相关,而胰岛素抵抗被认为是代谢综合征最重要的病理生理学特征。胰岛素抵抗是否参与这些皮肤病的发病过程,已有文献报道。本文主要从胰岛素抵抗参与皮肤病的发病机制方面进行阐述。

Insulin resistance refers to a pathological condition in which cells fail to respond sufficiently to insulin,leading to impaired glucose uptake and utilization.In recent years,some skin diseases have been found to be associated with metabolic syndrome,and insulin resistance is considered to be the most important pathophysiological feature of the metabolic syndrome.Recent literatures have described the role of insulin resistance in the pathogenesis of these skin diseases.This article elucidates the mechanisms of insulin resistance involved in skin diseases.