自噬调控多功能蛋白p62/SQSTM1参与肿瘤及其微环境的研究进展

Advances in autophagy-regulated multifunctional protein p62/SQSTM1 in tumor and its microenvironment

自噬是细胞内高度保守循环利用细胞代谢产物及陈旧细胞器的降解途径。自噬参与肿瘤的发生、发展及转移,甚至决定肿瘤预后。多功能蛋白p62/SQSTM1不仅作为重要的自噬接头蛋白参与降解过程,还是多个关键信号通路的调控枢纽,在肿瘤及其微环境中发挥了重要作用。本文综述p62/SQSTM1的结构功能及其作用机制的研究进展,旨在为利用自噬调节剂治疗肿瘤寻找关键突破点提供新的理论基础。

Autophagy is a highly evolutionary conserved metabolic pathway,through which metabolic products of cells and necrotic organelles are degraded into lysosomes and then recycled.Autophagy plays an important role in tumor formation,progression,and metastasis,and even determines the prognosis.Multifunctional protein p62/SQSTM1 not only participates in the degradation process as an important selective autophagy receptor,but also plays an essential key role in the regulation of multiple key signaling pathways.Thus,several studies have highlighted its promising effect in the tumors and tumor microenvironment.Understanding the structure,function,and mechanism of p62/SQSTM1 will provide new potential targets for anti-cancer strategies based on pharmacological modulation of autophagy targeting.