高压氧联合药物治疗脊柱术后谵妄的临床疗效观察

Effect of hyperbaric oxygen combined with medication on postoperative delirium after spine surgery

目的:探讨高压氧联合药物治疗脊柱术后谵妄的临床疗效。方法:选取2012年12月至2018年9月入住临沂市中心医院骨科的脊柱术后谵妄患者124例,依据患者或其家属的意愿分为高压氧加药物组和单纯药物组各62例。单纯药物组进行常规药物治疗,高压氧加药物组在常规药物治疗基础上增加高压氧治疗,2组治疗7 d后用简明精神病评定量表和临床总体印象量表评定临床疗效。结果:治疗前高压氧加药物组简明精神病评定量表、临床总体印象量表评分与单纯药物组比较差异无统计学意义( P>0.05)。治疗7 d后高压氧加药物组简明精神病评定量表评分为(20.2±2.7)分,临床总体印象量表评分为(2.05±0.73)分,均明显低于单纯药物组[(29.7±4.7)分、(3.99±1.70)分],差异均有统计学意义( P<0.05)。 结论:高压氧联合药物治疗脊柱术后谵妄能够更好地缓解临床症状,提高患者生活质量。

Objective To investigate the effect of hyperbaric oxygen(HBO)combined with medication in the treatment of postoperative delirium after spine surgery.Methods A total of 124 patients with postoperative delirium after spine surgery hospitalized from December 2012 to September 2018 were divided into the experimental group and the control group according to the preferences of patients or their relatives.Each group consisted of 62 patients.The control group received conventional medication,while the experimental group received HBO combined with conventional medication.After 7 days treatment,the clinical effects were evaluated by Brief Psychiatric Rating Scale(BPRS)and Clinical Global Impression Scale(CGIS).Results Before the treatments,there was no statistical significance of BPRS and CGIS between the experimental group and the control group(P>0.05).After 7 days treatment,the BPRS(20.2±2.7)and CGIS(2.05±0.73)of experimental group were significantly lower than those of the control group(29.7±4.7 and 3.99±1.70);the difference between the two groups was statistically significant(P<0.05).Conclusion HBO combined with medication in the treatment of postoperative delirium after spine surgery could better relieve clinical symptoms,therefore,improve patients′life quality.