中国大陆人群嗜吞噬细胞无形体血清阳性率的Meta分析

Meta-Analysis of the Seroprevalance of Anaplasmaphagocytophilum Among Chinese Mainland Population

目的采用Meta分析评价中国大陆人群嗜吞噬细胞无形体(anaplasmaphagocytophilum,AP)血清阳性率状况,为人粒细胞无形体病(human granulocytic anaplasmosis,HGA)的防治提供参考。方法计算机检索CNKI、VIP、WanFang Data和PubMed中英文数据库中有关中国大陆人群AP血清阳性率的相关文献。先确定文献纳入和排除标准,选定好文献提取相关数据,用Excel表格记录数据。再使用Rstudio软件进行中国大陆人群AP感染总阳性率的分析,以及性别、人群性质、年龄组的亚组分析。结果共有20篇文献符合标准纳入研究,经计算得出中国大陆地区AP血清阳性率合并值为17%(95%CI 0.11~0.23),其中男性合并后血清阳性率为15%(95%CI 0.02~0.39),女性资料合并后血清阳性率为10%(95%CI 0.04~0.17),P<0.01;健康人群资料合并后血清阳性率为13%(95%CI 0.08~0.20),高危人群资料合并后血清阳性率为20%(95%CI 0.10~0.32),P<0.01;≤54岁组合并后血清阳性率为24%(95%CI 0.11~0.40),55~69岁组合并后血清阳性率为24%(95%CI 0.06~0.49),≥70岁组合并后血清阳性率为22%(95%CI 0.07~0.42),P<0.01。20篇文献通过检测无发表偏倚。结论中国大陆人群嗜吞噬细胞无形体血清总阳性率虽不高,但是有潜在升高的趋势,值得引起广大医务工作者的注意以期提早进行防治。经本篇Meta分析,性别、人群性质可能为影响中国大陆人群嗜吞噬细胞无形体血清阳性率的因素。

Objectives Anaplasmaphagocytophilumin Chinese mainland popupation, in order to provide a reference for the prevention and treatment of human granulocytic anaplasmosis. Me thods Computer-researched literature on the seroprevalence of Anaplasmaphagocytophilum in Chinese mainland popupation was searched by Chinese and English databases-CNKI, VIP databases, Wan Fang Data and PubMed. First we determined the literature’s inclusion and exclusion criteria,selected the literature and extracted relevant data,and recorded data in an Excel spreadsheet. And Rstudio software was used to perform meta-analysis of the seropositivity rate of A. phagocytophilum among Chinese mainland popupation,as well as subgroup analysis of gender,population characteristics and age groups. Re s ults A total of20 articles were included in the study. After calculation, the combined seroprevalence of A. phagocytophilum in China's Mainland was 17%(95% CI 0.11-0.23), and the positive rate after male combination was 15%(95% CI0.02-0.39), the women’s A. phagocytophilum positive rate was 10%(95% CI 0.04-0.17), P <0.01;The seropositivity rate of healthy population data was 13%(95%CI 0.08-0.20) and the seropositivity rate of high-risk data group was 20%(95%CI 0.10-0.32), P<0.01. The positive rate of the age group ≤54 was 24%(95% CI0.11-0.40),age group 55-69 was 24%(95%CI 0.06-0.49), age group ≥70 was 22%(95%CI 0.07-0.42),P <0.01. 20 studies were tested as not publication biased.Conclus ion The total positive rate of A.phagocytophilum in Chinese mainland population is not high, but it has a potential increasing trend. It is worth making attention to the majority of medical workers in order to prevent and treat it early. According to this meta-analysis, gender and population characteristics may be factors influencing the seroprevalence of A.phagocytophilum in Chinese mainland population.