危重症肝病肝移植术后免疫抑制剂管理和感染的防治进展

Progress of immunosuppressant management,infection prevention and treatment after liver transplantation in severe liver disease

肝移植是危重症肝病的有效治疗手段,但是危重症肝病患者病理生理改变复杂,肝移植围手术期管理难度增大。因此,加强危重症肝病受者肝移植术后的管理具有重要意义。本文就危重症肝病的病理生理特点、肝移植术后免疫抑制药物选择、危重症肝病肝移植术后感染预防及治疗等方面做一综述。

Liver transplantation is an effective treatment of severe liver disease.However,the pathophysiological changes of patients with severe liver disease are complicated,which significantly increase the difficulty of perioperative management of liver transplantation.Therefore,it is of great significance to strengthen postoperative management of the recipients with severe liver disease after liver transplantation.In this article,the pathophysiological characteristics of severe liver disease,the selection of immunosuppressant after liver transplantation,and the prevention and treatment of infection after liver transplantation in patients with severe liver disease were summarized.