蒙药阿给镇痛作用的研究

Study on the Analgesic Activity of Artemisia Frigida

目的:研究蒙药阿给水提取物的镇痛作用。方法:将50只小鼠随机分为5组,即模型对照组、阿司匹林组(0.04g/kg)、阿给水提取物高、中、低剂量组(生药60.0、30.0、15.0g/kg),灌胃给药1次/d,连续给药7 d,采用乙酸扭体法记录各组小鼠出现扭体反应的潜伏期及15、内各小鼠扭体次数;另取50只雌性小鼠,同法分组、给药采用热板法测定小鼠给药前及给药30、45、60、90 min后的痛阈值。结果:与模型组相比,阿给提取物可显著减少小鼠15 min内扭体次数,延长给药15、30、60和90 min后的小鼠痛阈值(P<0.05)。结论:阿给水提取物具有明显的镇痛作用。

Objective To investigate the analgesic effects of mongolian medicine Agi water extract.Methods Fifty mice were randomly divided into model group(water),positive control group(aspirin,0.04 g/kg),high-dose,medium-dose and low-dose groups(60.0,30.0,15.0 g/kg)of water extract from Artemisia frigida.They were given relevant medicine intragastrically,once a day,for consecutive 7 d.The latency of writhing response and the number of writhing in each group were recorded by acetic acid stretching experiment.The pain threshold of mice before administration and 15,30,60,90 min after administration was measured by hot plate method.Result Compared with the model group,Agi water extract decreased the number of writhing in mice within 15 min,and extended pain thresholds of mice 15,30,60,90 min after medication(P<0.05).Conclusion Agi water extract had obvious analgesic effect.