广州地区128例新型冠状病毒感染患者的临床特征及预警指标分析

Analysis of Clinical Characteristics and Early Warning Indicators of 128 Patients with 2019-nCov Infection in Guangzhou Area

目的:分析广州地区2019新型冠状病毒感染患者的临床特点,寻找预后示警指标,为临床诊疗提供指导。方法:收集2020年1月23日至2020年2月20日在广州市第八人民医院集中收治的128例新型冠状病毒感染患者,按照诊断标准将患者分为轻型组(19例)、普通型组(99例)和重型组(10例),对其临床资料进行回顾性分析。结果:重型患者的症状如发热、干咳、乏力、胸闷、气促明显多于普通型及轻型患者。重型组患者的年龄、BMI明显高于轻型及普通型患者,血淋巴细胞、血清白蛋白水平明显低于普通型及轻型患者,而D-二聚体、血乳酸脱氢酶水平明显高于其他两型患者。结论:患者的年龄、BMI、LYM、ALB、LDH、D?dimer指标对新型冠状病毒感染患者有预警作用,上述指标方便易得,临床误差性小,且对患者无明显副作用,有助于新型冠状病毒感染患者病情的动态评估,有利于提高临床治愈率、降低危重患者的发生率。

Objective:To analyze the clinical characteristics of patients with 2019 novel coronavirus(2019?nCov)infection in Guangzhou area,to find prognostic warning indicators,and to provide guidance for clinical diagnosis and treatment.Methods:A total of 128 patients with 2019?nCov infection were collected from January 23,2020 to February 18,2020 in Guangzhou Eighth People′s Hospital.The patients were divided into light group(19 cases),normal group(99 cases)and severe group(10 cases)according to the diagnostic criteria.The clinical data were retrospectively analyzed.Results:Symptoms of severe patients such as fever,dry cough,fatigue,chest tightness,and shortness of breath were significantly more common than those of light and normal patients.The age and BMI of patients in the severe group were significantly higher than those of the light and normal patients.The levels of LYM and ALB were significantly lower than those of the light and normal patients,while the levels of D?dimer and LDH were significantly higher than those of other two types.Conclusion:The patient′s age,BMI,LYM,ALB,LDH,and D?dimer indexes have early warning effect on patients with 2019 novel coronavirus infection.The above indexes are convenient and easy to detect,the clinical error is small,and there are no obvious side effects on patients,which is helpful for dynamic assessment,is conducive to improving the clinical cure rate and reducing the incidence of critically ill patients.