摘要
足细胞是肾小球滤过屏障的重要组成部分,结构独特复杂。足细胞的细胞骨架决定着其形态、结构及对环境刺激的应答能力。足细胞突起部分由初级及次级突触构成。初级突触中的细胞骨架主要有微管与中间丝,次级突触即足突骨架则由肌动蛋白微丝组成。足细胞骨架蛋白受损会导致蛋白尿及肾小球疾病。而与细胞骨架成分有关的肾小球疾病,均可能在此亚细胞结构上寻找到治疗靶点。
The specific architecture of podocyte cytoskeleton plays a unique role in the glomerular filtration barrier,which regulate the shape,structure and the ability to response environmental stimuli.The processes of podocyte are consisted of primary and secondary parts.A primary processes of podocyte is supported by intermediate filaments and microtubules,while the secondary processes are mainly supported by actin filaments.Even a slight impairment of the cytoskeleton will lead to proteinuria and glomerular diseases.It is possible to find the therapic target from the cytoskeleton proteins in the related glomerular diseases.
作者
金英
张炯(综述)
王金泉(审校)
JIN Ying;ZHANG Jiong;WANG Jinquan(National Clinical Research Center of Kidney Diseases,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210016,China)
出处
《临床与病理杂志》
2020年第4期971-976,共6页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81470944)
国家重点研发计划(2018YFC1312705)。
关键词
足细胞细胞骨架
微管
中间丝
肌动蛋白
蛋白尿
podocyte cytoskeleton
microtubule
intermediate filament
actin
proteinuria
