摘要
目的回顾性分析两种不同再诱导方案治疗儿童急性淋巴细胞白血病(ALL)骨髓复发的短期疗效。方法回顾性选择57例骨髓复发的ALL患儿为研究对象,根据治疗方案分为VMDP组(长春新碱+米托蒽醌+地塞米松+培门冬酰胺酶,n=42)和VIDP组(长春新碱+去甲氧柔红霉素+地塞米松+培门冬酰胺酶,n=15)。分析比较两组完全缓解率和不良反应发生率。结果VMDP组和VIDP组完全缓解率(74%vs 73%)差异无统计学意义(P>0.05)。所有患儿均发生3级或3级以上的血液学不良事件,VMDP组化疗相关病死率低于VIDP组(P<0.05)。两组间感染发生率差异无统计学意义(P>0.05)。结论针对骨髓复发的儿童ALL,VMDP和VIDP再诱导方案均能获得较高的完全缓解率,且VMDP化疗方案引起的相关病死率更低,可作为儿童ALL骨髓复发再诱导方案的选择。
Objective To study the short-term effect of two different re-induction regimens in the treatment of acute lymphoblastic leukemia(ALL)children with bone marrow recurrence.Methods A retrospective analysis was performed for 57 ALL children with bone marrow recurrence.According to their treatment regimen,they were divided into two groups:VMDP(vincristine+mitoxantrone+dexamethasone+PEG-asparaginase;n=42)and VIDP(vincristine+idarubicin+dexamethasone+PEG-asparaginase;n=15).The two groups were compared in terms of complete response rate and incidence rate of adverse reactions.Results There was no significant difference in complete response rate between the VMDP and VIDP groups(74%vs 73%,P>0.05).All children experienced grade≥3 hematological adverse events.The VMDP group had a significantly lower chemotherapy-related mortality rate than the VIDP group(P<0.05).There was no significant difference in the incidence rate of infection between the two groups(P>0.05).Conclusions For ALL children with bone marrow recurrence,both re-induction regimens can achieve a relatively high complete response rate,and VMDP regimen has a lower chemotherapy-related mortality rate and can thus be used as an option for re-induction in ALL children with bone marrow recurrence.
作者
赵贝贝
陈晓娟
郭晔
杨文钰
邹尧
陈玉梅
张丽
阮敏
刘晓明
刘芳
刘天峰
戚本泉
竺晓凡
ZHAO Bei-Bei;CHEN Xiao-Juan;GUO Ye;YANG Wen-Yu;ZOU Yao;CHEN Yu-Mei;ZHANG Li;RUAN Min;LIU Xiao-Ming;LIU Fang;LIU Tian-Feng;QI Ben-Quan;ZHU Xiao-Fan(State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2020年第4期346-349,共4页
Chinese Journal of Contemporary Pediatrics
关键词
急性淋巴细胞白血病
骨髓复发
再诱导方案
儿童
Acute lymphoblastic leukemia
Marrow recurrence
Re-induction regimen
Child