早期脑梗死患者血清同型半胱氨酸的水平变化及意义

Changes and significance of serum homocysteine levels in patients with early cerebral infarction

目的探讨早期脑梗死患者血清同型半胱氨酸的水平变化及意义。方法选取我院2019年1~6月收治的50例早期脑梗死患者为观察组,选取同期在我院治疗的50例非脑梗死人群为对照组,两组均行血清同型半胱氨酸(Hcy)水平测定;并根据脑梗死患者病情将其分为轻度组、中度组及重度组,比较三组患者Hcy水平,并对三组患者神经功能缺损情况进行评估,分析Hcy与神经功能缺损之间的关系。结果重度组、中度组患者的Hcy水平、神经功能缺损评分均高于轻度组,差异有统计学意义(P<0.05);重度组患者的Hcy水平、神经功能缺损评分均高于中度组,差异有统计学意义(P<0.05);且脑梗死患者Hcy水平与临床神经功能缺损评分成正相关(r=0.81,P<0.05)。结论血清同型半胱氨酸可为早期脑梗死诊断及病情程度评估、预后评估中发挥积极的参考价值,且与神经功能缺损有较大的相关性。

Objective To investigate the changes and significance of serum homocysteine levels in patients with early cerebral infarction. Methods A total of 50 patients with early cerebral infarction admitted to our hospital from January to June 2019 were enrolled in the observation group. 50 patients with non-cerebral infarction in our hospital were selected as the control group. The level of cystine(Hcy) was determined. According to the condition of patients with cerebral infarction, they were divided into mild, moderate and severe groups. The Hcy levels of the three groups were compared, and the neurological deficits of the three groups were evaluated. The relationship between Hcy and neurological deficits were analysed. Results The Hcy and neurological deficit scores of patients in the severe and moderate groups were higher than those in the mild group, the difference was statistically significant(P<0.05). The Hcy and neurological deficit scores in the severe group were higher than those in the moderate group, the differences were statistically significant(P<0.05);and the Hcy level in patients with cerebral infarction was positively correlated with the clinical neurological deficit score(r=0.81, P<0.05). Conclusion Serum homocysteine can play a positive reference value for early diagnosis of cerebral infarction, assessment of disease severity and prognosis, and it has a greater correlation with neurological deficit.