潜阳育阴颗粒对急性脑梗死血压变异性及短期神经功能恢复的影响

The Influence of Qianyang Yuyin Granules on Acute Cerabral Infarction Patients in Blood Pressure Variability and Short-Term Nerve Functional Recovery

目的探讨潜阳育阴颗粒对阴虚阳亢型急性脑梗死患者的高血压、血压变异性(BPV)、短期神经功能恢复的影响。方法选取急性脑梗死伴有阴虚阳亢型高血压病史患者80例,随机分为治疗组和对照组各40例。对照组给服左旋氨氯地平降压治疗,治疗组在对照组治疗基础上加服潜阳育阴颗粒,治疗12周。采用无创性动态血压监测(ABPM)检测患者用药前后24 h动态血压并计算BPV;记录治疗前后的NIHSS评分、Barthel指数评分、阴虚阳亢证候评分。结果治疗后,治疗组患者24 h平均收缩压、24 h平均舒张压、日间平均收缩压、日间平均舒张压均较本组治疗前明显下降(P<0.01);与对照组相比,治疗组24 h平均收缩压、24 h平均舒张压、日间平均收缩压下降幅度更大(P<0.05)。治疗组患者24 h BPV水平均较治疗前明显降低(P<0.05~0.01);与对照组相比,治疗组各时间段BPV降低趋势更明显(P<0.05~0.01)。2组患者NIHSS评分、Barthel指数评分均优于治疗前(P<0.05~0.01);治疗组优于对照组(P<0.05)。治疗组阴虚阳亢证候明显减轻,评分明显低于治疗前(P<0.05~0.01),也明显低于对照组(P<0.05~0.01)。治疗组治疗12周后的病情加重率、复发率明显低于对照组(P<0.05)。结论潜阳育阴颗粒可有效改善阴虚阳亢型急性脑梗死合并高血压患者阴虚阳亢证候,进一步降低BPV,促进神经功能更好恢复。

OBJETIVE To discuss the influence of Qianyang Yuyin granules on acute cerabral infarction patients in high blood pressure,blood pressure variability(BPV)and short-term nerve functional recovery.METHODS 80 acute cerebral infarction patients accompanied by yin deficiency and yang hyperactivity predominant high blood pressure were enrolled and divided into the treatment group and the control group with 40 each.The control group was given levoamlodipine while the treatment was given Qianyang Yuyin granules as well as levoamlodipine.The course lasted for 12 weeks.Ambulatory blood pressure monitoring(ABPM)was taken to detect patients'ambulatory blood pressure in 24 h before and after administration and BPV was calculated.The scores of NIHSS,Barthel index,yin deficiency and yang hyperactivity syndrome were recorded.RESULTS After treatment,patients in the treatment group had significantly lower mean systolic pressure and diastolic pressure in 24 h and the daytime,respectively(P<0.01).Compared with the control group,systolic pressure and diastolic pressure in the daytime decreased more in the treatment group(P<0.05).Patients'24 h BPV decreased significantly(P<0.05,P<0.01)and that in the treatment group decreased more obviously in each period(P<0.05,P<0.01).The scores of NIHSS,Barthel index in two groups were better than those before treatment(P<0.05,P<0.01)and the treatment group were better(P<0.05).As for yin deficiency and yang hyperactivity syndrome,it was relieved significantly in the treatment group with lower score than that before treatment(P<0.05,P<0.01),which was much lower than that of the control group(P<0.05,P<0.01).The rates of aggravation and recurrence in the treatment group were much lower than those in the control group(P<0.05).CONCLUSION Qianyang Yuyin granules can effectively improve traditional Chinese medicine syndrome for patients with yin deficiency and yang hyperactivity predominant acute cerebral infarction accompanied by hypertension,resulting in lowering BPV and promoting the recovery for nerve function.