白细胞介素6对卵巢癌恶性演进的影响

Effect of interleukin6 on the malignant progression of ovarian cancer

现代肿瘤学认为,肿瘤相关性炎症是肿瘤微环境形成的显著特点之一。卵巢癌的发生和发展与微环境中的炎症因子的影响密不可分,白细胞介素6(interleukin 6,IL-6)就是调节肿瘤细胞生长的一种重要的促炎因子。研究发现,在卵巢癌患者中可检测到IL-6及其受体异常高表达,且IL-6升高与临床预后不良密切相关,IL-6对卵巢癌恶性演进的作用机制成为肿瘤微环境领域的研究热点。我们结合课题组近年来的研究成果,主要从IL-6与卵巢癌的增殖、侵袭和转移、血液系统的紊乱、耐药性,IL-6靶向治疗卵巢癌的研究现状和应用前景几方面进行综述。

Modern oncology believes that tumor-associated inflammation is one of the prominent features of tumor microenvironment.The occurrence and development of ovarian cancer is inseparable from the influence of inflammatory factors in the microenvironment.Interleukin-6(IL-6)is an important pro-inflammatory factor that regulates tumor cell growth.Current studies found that the expression of IL-6 and IL-6 receptor both increase in patients with ovarian cancer,which are closely related to poor clinical prognosis.The mechanism of effect of IL-6 on the malignant progression of ovarian cancer has been a research hotspots in the field of tumor microenvironment.In combination of the research results of this group in recent years,we mainly review the role of IL-6 in ovarian cancer including proliferation,invasion and metastasis,blood system disorders and drug resistance.Then,we introduce the research frontiers and application prospects of IL-6 targeted therapy for ovary cancer.